The hippocampal formation is comprised of several regions including the hippocampus and entorhinal cortex. The hippocampus and entorhinal cortex are widely associated with memory establishment, retainment, and spatial information integration. We know a lot about connectivity between these two regions in the adult brain and, in general, have a foundational understanding about the interaction between the two regions. However, we know very little about how the entorhinal cortex emerges and what genetic paradigms encode its unique layering and the cell types that emerge therein. Our goal is to understand the cell types diversity in the entorhinal cortex, along the dorsoventral axis, and how it emerges during development
Methods applied in this project are: transgenic mouse lines, single nuclei RNAsequencing, spatial transcriptomics, immunohistochemistry
Quattrocolo Lab 